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Books

  1. Birren B, Green E, Klapholz S, Myers R, Roskams AJ (eds) (1997) Genome Analysis: A Lab

Manual Vol. 1-4.  Cold Spring Harbor Press.


  1. Birren B, Green E, Klapholz S, Myers R, Roskams AJ (eds) (1998) Genome Analysis: A Lab Manual

Vol. 2.  Cold Spring Harbor Press.

  1. Birren B, Green E, Klapholz S, Myers R, Roskams AJ (eds) (1998) Genome Analysis: A Lab Manual Vol. 3.  Cold Spring Harbor Press.


  1. Birren B, Green E, Klapholz S, Myers R, Roskams AJ (eds) (1998) Genome Analysis: A Lab Manual Vol. 4.  Cold Spring Harbor Press.


  1. At the Helm: A Laboratory Navigator, Kathy Barker (Ed),  Jane Roskams (Developmental Editor) Cold Spring Harbor Press.


  1. Roskams AJ  and Rodgers L (2002) Lab Ref: A  handbook of recipes, reagents and other reference tools for use at the

bench Cold Spring Harbor Laboratory Press.

 

Publications

  1. Seira O, Wenchung Wang; Sharon Lee; Jane Roskams; Wolfram Tetzlaff .HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. Neurobiology of Aging, in press, Jun 2020

  2. Roskams J1, Popović Z2 Power to the People: Addressing Big Data Challenges in Neuroscience by Creating a New Cadre of Citizen Neuroscientists..Neuron. 2016 Nov 2;92(3):658-664. doi: 10.1016/j.neuron.2016.10.045.

  3. Joshua T Vogelstein, Katrin Amunts, Jane Roskams et al; Grand Challenges for Global Brain Science; Neurons and Cognition Section (qbio.NC) arXiv:1608.06548 Aug 2016

  4. Alkabie S, Basivireddy J, Zhou L, Roskams J, Rieckmann P, Quandt JA. SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties.J Neuroinflammation. 2016 Aug 31;13(1):225. doi: 10.1186/s12974-016-0657-9.PMID:27581191

  5. Peng H, Hawrylycz M, Roskams J, Hill S, Spruston N, Meijering E, Ascoli GA.BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images. Neuron. 2015 Jul 15;87(2):252-6. doi: 10.1016/j.neuron.2015.06.036.PMID:26182412

  6. Ashe J, Roskams J.Marie T. Filbin: in memoriam. Neuron. 2014 May 7;82(3):509-10. No abstract available. PMID:24921102

  7. York EM, Petit A, Roskams AJ.  Epigenetics of neural repair following spinal cord injury. Neurotherapeutics. 2013 Oct;10(4):757-70. doi: 10.1007/s13311-013-0228-z. Review.

  8. Foti SB, Chou A, Moll AD, Roskams AJ.  HDAC inhibitors dysregulate neural stem cell activity in the postnatal mouse brain. Int J Dev Neurosci. 2013 Mar 27. doi:pii: S0736-5748(13)00044-0. 10.1016/j.ijdevneu.2013.03.008. [Epub ahead of print]PMID: 23542004

  9.  Lloyd-Burton SM, York EM, Anwar MA, Vincent AJ, Roskams AJ.SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia.J Neurosci. 2013 Mar 6;33(10):4468-81. doi: 10.1523/JNEUROSCI.3585-12.2013.PMID: 23467362

  10. Murdoch B, Roskams AJ. Fibroblast growth factor signaling regulates neurogenesis at multiple stages in the embryonic olfactory epithelium. Stem Cells Dev. 2013 Feb

  11. 15;22(4):525-37. doi: 10.1089/scd.2012.0406. Epub 2013 Jan 11. PMID: 23137310

  12. Witheford M, Westendorf K, Roskams AJ OECs promote CST Axonal Outgrowth By a L1-Dependent Mechanism. Glia (in press, Aug 2013)

  13. Foti SB and Roskams AJ A Tale Of Two Epiphenomena: The Complex Interplay Of Epigenetics And Epilepsy. Epilepsy, InTech (invited review), May 2011

  14. Lloyd-Burton S and Roskams AJ  SPARC Like-1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS.  J Comp Neurol. 2011 Dec 15. doi: 10.1002/cne23029

  15. *Audrey Petit1, *Ashley D. Sanders1, Timothy E. Kennedy2, Wolfram Tetzlaff1, Katie J. Glattfelder3, Rachel A. Dalley3, Ralph B. Puchalski3, Allan R. Jones3, Roskams AJ, Adult Spinal Cord Radial Glia Display a Unique Progenitor Phenotype. PLoS One. 2011;6(9):e24538. doi: 10.1371/journal.pone.0024538. Epub 2011 Sep 12.

  16. Laffita-Mesa JM, Bauer PO, Kourí V, Peña Serrano L, Roskams J, Almaguer Gotay D, Montes Brown JC, Martínez Rodríguez PA, González-Zaldívar Y, Almaguer Mederos L, Cuello-Almarales D, Aguiar Santiago J. Epigenetics DNA methylation in the core ataxin-2 gene promoter: novel physiological and pathological implications. Hum Genet. 2011 Oct 30

  17. Bretzner F, Liu J, Bajgoric T, Currie E, Roskams AJ, and Tetzlaff W* Undesired effects of a combinatorial treatment for spinal cord injury: Transplantation of  olfactory ensheathing cells with BDNF treatment of rubrospinal neurons J Neurosci Res. 2010 Oct;88(13):2833-46

  18. MacDonald J, Berndt A, Verster A and Roskams AJ. MBD2 and MeCP2 Regulate Sequential Checkpoints in Olfactory Receptor Neuron Developmen Mol Cell Neurosci. 2010 May;44(1):55-67. Epub 2010 Feb 24.

  19. Bretzner F, Plemel JR, Liu J, Richter M, Roskams AJ, Tetzlaff W. Combination of olfactory ensheathing cells with local versus systemic cAMP treatment after a cervical rubrospinal tract injury. J Neurosci Res. 2010 Oct;88(13):2833-46.

  20. Richter MW and Roskams AJ  Corticospinal neurons respond Differentially to Neurotrophins and MAG in Vitro, Journal of Neuroscience Research, 2009 Aug 1;87(10):2222-36

  21. *MacDonald J and Roskams AJ. regulation of nervous system development by DNA methylation and histone deacetylation. Prog. Neurbiol. 2009 Jul;88(3):170-83.

  22. Richter MW, Roskams AJ. Olfactory ensheathing cell transplantation following spinal cord injury: hype or hope? Exp Neurol. 2008 Feb;209(2):353-67. Epub 2007 Jun 30. Review.

  23. Vincent AJ, Lau P and Roskams AJ. SPARC is Expressed at Discrete Stages of Glial Development in the CNS and PNS, Dev Dyn. 2008 May;237(5)

  24. Richter M, Westendorf K and Roskams AJ. Culturing Olfactory Ensheathing Cells from Neonatal and Adult Olfactory Mucosa. Methods Mol Biol. 2008;438:95-102.

  25. Murdoch, B. & Roskams, AJ. A Novel Embryonic Nestin-Expressing Radial Glia-Like Progenitor Gives Rise To Spatially Restricted Chemosensory Neurons. J Neurosci. 2008 Apr 16;28(16):4271-82

  26. Barnett SC, Roskams AJ. Olfactory ensheathing cells: isolation and culture from the neonatal olfactory bulb. Methods Mol Biol. 2008;438:85-94.

  27. Bretzner F, Liu J, Currie E, Roskams AJ, Tetzlaff W. Undesired effects of a combinatorial treatment for spinal cord injury--transplantation of olfactory ensheathing cells and BDNF infusion to the red nucleus. Eur J Neurosci. 2008 Nov;28(9):1795-807.

  28. Richter, M., Au, E. & Roskams, AJ. The Cell and Developmental Biology of Olfactory Ensheathing Cells. Glia invited review (accepted, Sept 2008).

  29. *MacDonald J and Roskams AJ. HDAC1 and HDAC2 Are Induced at Distinct Stages in CNS Neuronal and Glial Lineages , Dev Dyn. 2008 Aug;23 7(8):2256-67.

  30. Murdoch B, Roskams AJ. Olfactory epithelium progenitors: insights from transgenic mice and in vitro biology. J Mol Histol. 2007 Dec;38(6):581-99. Epub 2007 Sep 13. [3]

  31. *Edmund Au, *Miranda W Richter, *#Wolfram Tetzlaff, **Ruedi Aebersold, ***E Helene Sage, and *A. Jane Roskams, SPARC is Secreted by Olfactory Ensheathing Cells to Stimulate Neurite Outgrowth and CNS Repair, J Neurosci 27, 7208-7221 (2007).

  32. Oswald Steward. Ph.D.1§ , Kelli Sharp1, *Edmund Au2 , Gowri Selvan, Ph.D.1, Anthony Hadden, M.D.1, Maura Hofstadter, Ph.D.1, Jane Roskams, Ph.D.2A Re-assessment of the Consequences of Delayed Transplantation of Olfactory Ensheathing Cells Following Complete Spinal Cord Transection In Rats. Exp Neurol. 2006 Apr;198(2):483-99. Epub 2006 Feb 21.

  33. *Carson C, *Murdoch B, *Lazzari N and Roskams AJ: Notch and Its Ligands display dynamic patterns of expression in the developing olfactory system. Dev Dyn. 2006 Jun;235(6):1678-88

  34. Paul Lu, Hong Yang, Maya Culbertson, Lori Graham, A. Jane Roskams and Mark H. Tuszynski.  Olfactory Ensheathing Cells Exhibit Minimal Migratory and Axonal Growth-Promoting Properties After Spinal Cord Injury. J. Neuroscience 2006 Oct 25; 26(43):11120-30.

  35. Roskams AJ and Tetzlaff W, Directing Stem Cells and Progenitor Cells on the Stage of Spinal Cord Injury. Exp Neurol. 2005 Jun;193(2):267-72.

  36. *Carson C, Saleh M, *Fung FW, Nicholson DW and Roskams AJ. Axonal dynactin p150 glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis. J. Neurosci. 2005 Jun 29;25(26):6092-6104 ** Chosen as a “Highlight in the Journal” and for “News and Views” commentary.

  37. *Richter M, *Au E, Liu J Tetzlaff W and Roskams AJ.. Lamina Propria And Olfactory Bulb Ensheathing Cells Exhibit Differential Integration, Migration, And Promote Differential Axon Sprouting In The Lesioned Spinal Cord.  J. Neurosci. 2005 Nov 16;25(46):10700-11 ** Chosen as a “Highlight in the Journal”

  38. *MacDonald JL, *Gin, CSY and Roskams AJ. Stage-Specific Induction of DNA Methyltransferases in Olfactory Receptor Neuron Development. Developmental Biology, Dec 15 2005 Vol 288 pp 461-473

  39. Ramer L, Au E, Richter M, Liu J, Tetzlaff W and Roskams AJ. Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injury. J Comp Neurol. 2004 May 17;473(1):1-15.

  40. Cowan C and Roskams J. Caspase-3 and caspase-9 mediate developmental apoptosis in the mouse olfactory system. J Comp Neurol. 2004 Jun 14;474(1):136-48.

  41. Ramer LM*, Richter, MW*, Roskams AJ, Tetzlaff W, Ramer M. Peripherally-derived olfactory ensheathing cells do not promote primary afferent regeneration following dorsal root injury. Glia. 2004 Aug;47(2):189-206. (* Co-first authors)

  42. Carter, L, MacDonald J and Roskams AJ. Olfactory horizontal basal cells demonstrate a conserved multipotent progenitor phenotype J. Neuroscience 2004 Jun 23;24(25):5670-83

  43. Au E, Roskams AJ. Olfactory ensheathing cells of the lamina propria in vivo and in vitro.  Glia. 2003 Feb;41(3):224-36.

  44. Hegg CC, Au E, Roskams AJ, Lucero MT. PACAP is Present in the Olfactory System and Evokes Calcium Transients in Olfactory Receptor Neurons. J Neurophysiol. 2003 May 21.

  45. Cowan CM, Roskams AJ. Apoptosis in the mature and developing olfactory neuroepithelium. Microsc Res Tech. 2002 Aug 1;58(3):204-15.

  46. Carter LA, Roskams AJ. Neurotrophins and their receptors in the primary  olfactory neuraxis. Microsc Res Tech. 2002 Aug 1;58(3):189-96.

  47. Illing N, Boolay S, Siwoski JS, Casper D, Lucero MT, Roskams AJ. Conditionally immortalized clonal cell lines from the mouse olfactory placode differentiate into olfactory receptor neurons. Mol Cell Neurosci. 2002 Jun;20(2):225-43.

  48. Au E, Roskams AJ. Culturing olfactory ensheathing glia from the mouse olfactory epithelium. Methods Mol Biol. 2002;198:49-54.

  49. Barnett SC, Roskams AJ. Olfactory ensheathing cells. Isolation and culture from the rat olfactory bulb. Methods Mol Biol. 2002;198:41-8.

  50. Gilbert M, Smith J, Roskams AJ, Auld VJ. Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia. Glia. 2001 May;34(3):151-64

  51. Cowan CM, Thai J, Krajewski S, Reed JC, Nicholson DW, Kaufmann SH, Roskams AJ. Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons. J Neurosci. 2001 Sep 15;21(18):7099-109.

  52. Roskams AJI, Cai X, Ronnett GV.  (1998) Expression of neuron-specific beta-III tubulin during olfactory neurogenesis in the embryonic and adult rat. Neurosc. 83(1): 191-200. Sisodia SS, Thinakaran G, Roskams AJ, Slunt HH, VonKoch CS, Price DL. (1996) Studies on the metabolism and biological function of APLP2  In: Mechanisms of Neurodegenerative Disease.  Annals of the NY Acad. Sci. 777:77-81.

  53.  Roskams AJI, Bethel AM, Hurt KJ, Ronnett GV.  (1996)  Sequential expression of Trks A, B and C in the regenerating olfactory epithelium. J. Neurosc.  16(4):1294-1307.

  54. Cameron AM, Steiner JP, Roskams AJI, Ali S, Ronnett GV, Snyder SH.  (1995)  Calcineurin associated with the inositol 1,4,5- triphosphate receptor-FKBP12 complex modulates Ca2 flux.  Cell  83(3): 463-721-2.

  55. Altus M, Wood CM, Stewart DA, Roskams AJI, Oliphant A, Owens GA, Skolnick M, Danner DB, McClung JK.  (1995)  Regions of evolutionary conservation between rat and human prohibitin-encoding genes.  Gene  158(2):291-294.

  56. Wood CM, Roskams AJI, Stewart DA, Altus M, Owens GA, Danner DB, McClung JK, Marsh JL. (1995) The Cc gene encodes the drosophilia homolog of prohibitin, a mammalian antiproliferative protein. Genes and Develop. 53:91-95.

  57. Walensky L, Roskams AJI, Lefkowitz RJ, Snyder SH, Ronnett GV.  (1995) Odorant receptors and desensitization proteins colocalize in mammalian sperm.  Mol. Med.  1(2)130-141.

  58. Thinakaran G*, Roskams AJI*, Slunt HH, Kitt CA, von Koch C, Reed RR, Price DL, Sisodia S.  (1995) Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis. J. Neurosc.  15(10):6314-6326.

  59. Roskams AJI, Friedman V, Wood CM, Owens GA, Stewart DA, Danner DB, McClung  JK.  (1993) Cell cycle activity and expression of Prohibitin mRNA.  J. Cell Phys.  157:289-295

  60. Roskams AJ, Connor JR. (1993) Alterations in transferrin and its receptor in the brain of myelin-deficient rats.  In: Duncan ID, Skoff RP, Colman D (eds) Myelination and Dysmyelination.  Annals of the NY Acad. Sci. 265:391-393.

  61. Roskams AJI, Bredt DS, Dawson TM, Ronnett GV.  (1994)  Nitric oxide mediates the formation of synaptic connections in developing and regenerating rat olfactory neurons.  Neuron  13:289-299.

  62. Miller MW, Roskams AJI, Connor JR.  (1995)  Iron regulation in the developing rat brain: effect of in utero ethanol exposure.  J. Neurochem.  65:373-380.

  63. Roskams AJI, Connor JR.  (1994) Iron, transferrin and ferritin in the rat brain during        development and aging.  J. Neurochem.  63(2):709-716.

  64. Connor JR, Roskams AJ, Williams MW, Menzies SL.  (1993) Regulation of transferrin expression of the central nervous system of a myelin mutant, the Shiverer mouse.  J. Neurosc. Res.  36:501-507.

  65. Roskams AJ, Connor JR.  (1992) Transferrin receptor expression in myelin deficient (md) rats.  J. Neurosc Res. 31:421-427.

  66. Roskams AJ, Connor JR. (1991)  Aluminum access to the brain: a role for transferrin and its receptor.  “Literature Highlight”. Cerebrovasc. and Brain Metab. Rev 3(2):169.

  67. Roskams AJ, Connor JR.  (1990)  Aluminum access to the brain: a role for transferrin and its receptor.  Proc. Ntl. Acad. Sci. USA 87 (22):9024-9027.

  68. Balaban CD, Roskams AJ, Severs WB.  (1988)  Diazepam attenuation of somatostatin-induced motor disturbances and neurotoxicity.  Brain Research  458:91-96.